Winstrol is a very popular oral or injectable anabolic-androgenic steroid. It ranks up there with deca and dianabol as the most widely used and abused drug by competitive athletes.
Stanozolol is commonly refered to as winny (winstrol). Winstrol comes in two forms as mentioned above – both oral and injectable. The injections are the same methylated compound as the oral form of the drug. However, due to this feature, it cannot be esterified for time release. Winstrol has a short active life of around 8 hours.
Winstrol counteracts estrogenic side effects such as gyno and water retention – another quality which makes it attractive to the athlete seeking lean mass gains. Winstrol is a 5-alpha reduced substrate. 5-alpha reduction breaks the double bond between positions 4 and 5, which is what is required for aromatase to convert to estrogen. Aromatase is the primary enzyme used for the manufacturing of estrogen within the male body. For avoiding gyno, winstrol is well suited.
Since winstrol is not capable of converting into estrogen, anti-estrogen ancillary drugs such as nolvadex or clomid are not necessary when using this steroid. Gyno will not be a concern for even the most sensitive individuals when using this steroid. Winstrol is excellent for lean gains since water retention is reduced when using this steroid. This is due to the fact that estrogen is the cause of water retention. It is excellent to use among athletes who are seeking for a combination of both strength and speed.
Letrozole is primarily used to ward any estrogenic side effects caused by the administration of anabolic steroids. Letrozole has been show to have the capability of reducing the level of estrogen in users’ bodies by up to 96-98%. This would seemingly be enough in itself to make the compound a desirable one with which steroid users would be interested in. However letrozole also has been shown to increase the amount of lutenizing hormone, follicle stimulating hormone, and sex hormone binding globulin in users (1). When you combine these attributes with the fact that it will help protect against gynocomastia, water retention and other estrogenic side effects letrozole obviously can fulfill many users’ needs.
Interestingly, it takes approximately 60 days to get a steady blood plasma level of letrozole once administration of the drug begins. This may necessitate that a user begin using the compound prior to beginning their cycle if they wish for the effects to be at full strength once their cycle begins. This may also hinder the ability of the compound to respond quickly if a user begins administration of the drug to counteract some side effects that have appeared quickly.
Mesterolone is an orally active, 1-methylated DHT. Like Masteron, but then actually delivered in an oral fashion. DHT is the conversion product of testosterone at the 5-alpha-reductase enzyme, the result being a hormone that is 3 to 4 times as androgenic and is structurally incapable of forming estrogen. One would imagine then that mesterolone would be a perfect drug to enhance strength and add small but completely lean gains to the frame. Unfortunately there is a control mechanism for DHT in the human body. When levels get too high, the 3alpha hydroxysteroid dehydrogenase enzyme converts it to a mostly inactive compound known as 3-alpha (5-alpha-androstan-3alpha,17beta-diol), a prohormone if you will. It can equally convert back to DHT by way of the same enzyme when low levels of DHT are detected. But it means that unless one uses ridiculously high amounts, most of what is administered is quite useless at the height of the androgen receptor in muscle tissue and thus mesterolone is not particularly suited, if at all, to promote muscle hypertrophy.
Proviron has four distinct uses in the world of bodybuilding. The first being the result of its structure. It is 5-alpha reduced and not capable of forming estrogen, yet it nonetheless has a much higher affinity for the aromatase enzyme (which converts testosterone to estrogen) than testosterone does. That means in administering it with testosterone or another aromatizable compound, it prevents estrogen build-up because it binds to the aromatase enzyme very strongly, thereby preventing these steroids from interacting with it and forming estrogen. So Mesterolone use has the extreme benefit of reducing estrogenic side-effects and water retention noted with other steroids, and as such still help to provide mostly lean gains. Its also been suggested that it may actually downgrade the actual estrogen receptor making it doubly effective at reducing circulating estrogen levels.